using IronXL;
using System.Data;
using System.Data.SqlClient;

// Supported for XLSX, XLS, XLSM, XLTX, CSV and TSV
WorkBook workBook = WorkBook.Load("sample.xlsx");

// Convert the workbook to ToDataSet
DataSet dataSet = workBook.ToDataSet();

// Your sql query
string sql = "SELECT * FROM Users";

// Your connection string
string connectionString = @"Data Source=.\SQLEXPRESS;Initial Catalog=usersdb;Integrated Security=True";
using (SqlConnection connection = new SqlConnection(connectionString))
{
    // Open connections to the database
    connection.Open();
    SqlDataAdapter adapter = new SqlDataAdapter(sql, connection);

    // Update the values in database using the values in Excel
    adapter.Update(dataSet);
}

Imports IronXL
Imports System.Data
Imports System.Data.SqlClient

' Supported for XLSX, XLS, XLSM, XLTX, CSV and TSV
Private workBook As WorkBook = WorkBook.Load("sample.xlsx")

' Convert the workbook to ToDataSet
Private dataSet As DataSet = workBook.ToDataSet()

' Your sql query
Private sql As String = "SELECT * FROM Users"

' Your connection string
Private connectionString As String = "Data Source=.\SQLEXPRESS;Initial Catalog=usersdb;Integrated Security=True"
Using connection As New SqlConnection(connectionString)
	' Open connections to the database
	connection.Open()
	Dim adapter As New SqlDataAdapter(sql, connection)

	' Update the values in database using the values in Excel
	adapter.Update(dataSet)
End Using